2013 new Mac Pro will not boot up from and external hard drive

New 2013 MAC PRO running Yosemite will not not see a bootable external hard drive when starting up using option key?  Same External hard drive will boot up on 2013 Mac Book Pro running Yosemite.

Reading between tea leaves sometimes leaves some things to imagination.
You used SuperDuper latest version that was recently upgraded for Yosemite on a laptop running 10.10 (or even 10.9.3+) that is in a X-brand USB3 drive enclosure, not bus powered btw, moved it to the nMP and plugged it into a direct port, not going through a hub (monitors have hubs of course and there is only one real bus+controller on the nMP that ALL USB3 travels through.
Thunderbolt and self-powered would be nice but they cost a bit more.
I have read where Carbon Copy Cloner (now v 4.x) worked where others failed. I use to use both but have used CCC since its inception and use back in 10.2.2 forward along with SD! for a few years based on comments here.
Drivers missing? someone compared system extensions and found the ones needed for say the nMP are not there? how about running a 10.10.1 combo update and see if that changes - we USE to be able to apply updates to a system that we were not booted from, very handy (could update a sparse disk image of a system that way, one created with CCC).
WD Passports seem popular with laptop users, but they come here to this forum complaining that it doesn't work, disappears off the bus (spins down goes to sleep, acts like a green drive acts).

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    replace the system drive
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    Tony,
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    Message was edited by: jlseattle74

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