Another "An error occurred when attempting to change modules" error

Hello all:
After using Adobe Photoshop Lightroom on Mac OSX trouble free for the past 6 months, I opened up Lightroom today and received the following error: "An error occurred when attempting to change modules." I had not made any changes in between when it worked normally and when the error started to occur. I beleive the last thing I did before this error occurred was to go into the Print Module.
Other information--I keep all my RAW .NEF files on an external Firewire (800) 750 GB drive. This is on Mac OS X 10.5 running Adobe Photoshop Lightroom 1.3 and also with 1.4.1. I'm running an iMac 20" with dual-core 2.2 Ghz Intel processors and 4 GB of RAM. I have around 25k images total.
When I noticed this problem, I was on Lightroom 1.3. I immediately upgraded to 1.4.1, which did not solve the problem. I have also tried many suggestions in the forums including uninstalling the application and removing the .plist file.
I thought I had come up with a solution by creating a new catalog, then importing the former into it. While this seems to work immediately after the import process, as soon as I close it, the problem manifests itself again.
More details that may or (likely) may not help:
- Going to the Develop and Print Modules gives me no problems. However, when I click on Library, Slideshow, or Web, I see the error.
- I upgraded my Mac to the latest patch level after observing this error to no avail.
So it looks like my choices are to create a new file and reimport every single time, or lose all of the work I've done for the past 6 months on thousands of images.
Can anyone please help???? I promise to post the solution when we fix this darn thing so others may benefit. I'd be happy to run through any troubleshooting that y'all would suggest outside of switching to a Canon.
Thanks!!!!
Matt

I'd first check for the existence of a file ending in .lock, which should be present when LR is in use, but if it exists when LR is quit, it can cause problems, and should be deleted.
Please post back your results.

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