Can not open .psd files in Photoshop!

I am using Photoshop CS4 11.0.1 (Macintosh 10.5.6). Files created in Photoshop are saved to disc as .psd. Next time upon opening (both double clicking file and opening from within Photoshop) message appears: ‘Could not complete your request because the file is empty’ (I can see the file and ‘look’ at it using space bar). Older .psd files open normally. I did start using Spaces a few days ago. Maybe that's the culprit? Any ideas?

That sounds like the files are corrupted.  I would be looking for disk problems.
And you really should be on MacOS 10.5.8 - they fix a lot of bugs with each dot release.

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