Can't open mail after update

I am getting an error message saying that mail can't open because the newer version may be located elsewhere than in applications.  I have checked and I have versions 4.5 and 4.6 in applications.  I have followed instructions in help to reinstall Mac OS and security update then try mail again, but it still doesn't work.  Do I need to delete 4.5?  Sounds daft to you experts I'm sure, but am worried I will lose all my emails if I do so.  Also, seems that Adobe wants to open all files as default, but I can't figure out how to change that (in case that's the problem).  Would love some help, please.

Delete 4.5. I would then go through the steps again (see here). It won't lose your setting or messages.
Select a file that Adobe is opening, Command-I to bring up the Info window, choose what it should be opened with, then click Change All.

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