Can't turn mute off / iTunes won't play

After a blue screen restart into safe mode this morning, I have lost all sound. System Preferences lists it as mute, but won't let me change the setting. The volume keys do nothing and I can't adjust using the icon in the menu bar.
While trying to work out the extent of the problem, I have noticed that iTunes won't play.
The computer blue-screened after I downloaded the latest security update. I thought it was because my startup disc was full and after I restarted, I got rid of some of the excess. Everything seemed fine so I downloaded the iTunes update (at the time I didn't realise that the sound wasn't working).
Any suggestions?
Cheers,
Kate Buchanan

all well - though the first restart did nowt, the second gave me large amounts of joy

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Can't turn mute off / iTunes won't play

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