Computer not responding after waking

Occasionally, but not all the time, after I put my computer to sleep it doesn't like to wake back up. Last night it did it again, and the only programs that were running when I put it to bed were: Finder, FireFox, iChat, iTunes, Entourage, Garage Band, and Activity Monitor. I didn't have my external display hooked up, but I do have a USB hub with a Wacon pen tablet, a HP 3100 Printer, and an Epson R300 printer. I also have a 500gig MyBook connected via FireWire.
Any ideas?

Try resetting the System Management Controller:
1. Turn off computer, take out battery and unplug AC power.
2. Hold down power button for 5 seconds.
3. Put battery back in, connect AC if you want, and turn computer back on
The System Management Controller controls things like backlighting, hard disk spin down, sleep and wake issues, etc. Hopefully this should help you out.
http://docs.info.apple.com/article.html?artnum=303319

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