Could not save Preferences because the file is locked?

Every time I launch Photoshop I have to reload third party extensions, and re-do preferences settings.
When I quit, I get a warning icon.
Could not save Preferences because the file is locked, you do not have necessary access permissions, or another program is using the file. Use the ‘Get Info’ command in the Finder to ensure the file is unlocked and you have permission to acess the file.
Any ideas?
thanks

Solved it after 8 hours of trying.
Hold down "Command" "option" and "shift" keys and open Photoshop. It will ask if you want to delete settings. Say Yes. You will have to reset everything but it clears the problem away instantly.

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