CS5 and 6 slow down issue - was working fine

Hi Everyone
Hoping you can help as i've tried pretty much everything I can think of to resolve this. I've been running CS5.5 production premium for a while now, powerful PC, everything was running fast and working great.
Now, all of a sudden Photoshop keeps slowing down to a crawl - im talking massive slow down, the mouse cursor doesnt even move properly. No hardware has changed, and no major software changes, all CS5 is up to date. All my other CS programs (after effects, illustrator etc) are working fine. Tried re-installing CS5, I also installed the PS CS6 trial to see if that works, but it also suffers from the same slow down issue.
So if anyone has any ideas, I would really appreciate them! Before I have to do a complete clean install of the whole system.
Thanks
Jack

More details on your set-up might be helpful.
Boilerplate-text:
Are Photoshop and OS fully updated and have you performed the usual trouble-shooting routines (trashing prefs by keeping command-alt-shift/ctrl-alt-shift pressed while starting Photoshop after making sure all customized presets like Actions, Patterns, Brushes etc. have been saved and making a note of the Preferences you’ve changed, 3rd party plug-ins deactivation, system maintenance, cleaning caches, font validation, etc.)?

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