Does the cache matter when choosing hard drive for mac pro?

Hi,
I have been looking at all the specs to see about adding another hard drive to my mac pro. It is the 1st generation 2006 duel. I am getting a bit confused about the specs required! I don't understand cache? I think that mine is 8 cache, but a lot of the drives I am looking at are 16 or more. Is this important, have I got to stick to 8? Also does it matter about which Sata? i.e. 1, 11 or 111? and what does 'low profile' mean? Fitting it seems really easy, but buying the wrong drive seems easy as well!
Thanks for any help,
Adrian.

Desktop drives are nominal 3.5" form factors, about one inch tall. They use a 12 Volt motor to spin the heavy platters around fairly fast.
Notebook rotating drives are mostly 2.5" form factor, now mostly around 9.5mm tall, possibly less. They have only 5 Volts available to spin the motor.
SATA 1, 2, 3 -- 1.5, 3.0 and 6.0 is all specsmanship -- rotating drives cannot source data off the spinning platters faster than  a burst of about 150 Mbytes/sec (1.2 Mbits/sec). So that part does not matter except that the 1.5 drives will be older models. Do note pay extra for better SATA speeds.
Rotation speed is very important, because that determines how fast the bits can fly past the read head. 5400 RPM is slower than 7200 RPM. A few 10,000 RPM drives are available, but they are too pricey for most users. I use 10,000 RPM drives in my Server. For Desktop computers, DO pay extra for 7200 over 5400. For notebook computers, a few 7200 RPM drives are available, but they sometimes run HOT.
Green drives, on the other hand, take great liberties with spin rates and sleeping, and are not suitable for production (great for Backups, but then they are not candidates for spares for your main drives). For these reasons, I do not own any Green Drives.
Large-enough cache size means the drive can read an entire track in one revolution, so that if you next ask for blocks near the original block you will not wait the average 4.166 milliseconds for the platter to spin halfway around to pick up new data (it is waiting, pre-fetched in the cache). So do not pay extra above about 8Mbytes, but use larger cache size as a tie breaker between equivalent models.

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