Error: X "does not have permission to write to the application's directory! Are you running off a disk image? If not, ask your system administrator for help."

I have received to following error from at least three different applications when they have attempted to auto-update recently: X "does not have permission to write to the application's directory! Are you running off a disk image? If not, ask your system administrator for help." 
I am not running off a disk image and I have admin privileges... Not sure what the problem is, but it just started happening (a week or two ago) and I have never previously had a problem with these applications auto-updating.  I have repaired permissions and attempted other "fixes" found on the interweb, but nothing works.  Also, this is only happening on my iMac (27" Intel i5) and not my MacBook Pro (17" Intel i5) -- both are running Lion.  Please help!

If you updated using the default install (merge) from before Tiger, you may be seeing an issue that we saw when Leopard first came out last year.
Not sure of the fix - it was not simple - but if you search back in these forums you might find something that will help. I believe it deals with the numbers assigned to accounts (501, etc).
If you open your Accounts Preferences and unlock the padlock, right-click Advanced Options and read your User ID and Group ID. Let us know what they are.
Now, in the other user admin account, do the same thing.
One of the real experts who knows much more about this than I may be able to then help.
And be sure to check out this article
http://pinkmutant.com/articles/Leopard/leobugs.html

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