Excel .xlsx "document not saved"

I have migrated a workbook from Microsoft excel 2010 to my new iMac. I have made several updates. It is now giving the above message.
I have looked at Help which says the .xlsx extn is fine. I have tried saving a copy but it still gives the same message.
What do I do please?
Thank you

I guess I must be!! It came with the Microsoft Office  for iMac installed when I bought in around April 2013.

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