Firefox will not open when I click on it. It won't even let me open the profile manager. Uninstalling it and re-installing it does nothing. And it is driving me insane. I need firefox.

It will not open. No matter what I do.

A possible cause is security software (firewall) that blocks or restricts Firefox or the plugin-container process without informing you, possibly after detecting changes (update) to the Firefox program.
Remove all rules for Firefox from the permissions list in the firewall and let your firewall ask again for permission to get full unrestricted access to internet for Firefox and the plugin-container process and the updater process.
See:
* https://support.mozilla.com/kb/Server+not+found
* https://support.mozilla.com/kb/Firewalls

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    When I go to "clear recent history" and click on "clear now" it immediately states that the program is not responding. Does the same after reboot. It's not letting me clear my history, and I've tried 6 times, all with the same results... I have to close the program from the task manager. Is there a fix?

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    * http://kb.mozillazine.org/Using_multiple_profiles_-_Firefox
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    * http://dmcritchie.mvps.org/icons/win7_quicklaunch_large.png
    * http://dmcritchie.mvps.org/firefox/quicklaunch.htm
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    * http://dmcritchie.mvps.org/firefox/firefox.htm#launchy
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