First time using garageband no signal for live instrument -- please help!

the project i'm currently working on is remixing 4-track masters on a tascam 424 mkII into digital files on garageband.
i have an m-audio mobilepre, that i've hooked up and i've changed the audio settings on my computer so that all input and output is through the mobilepre. i can't get a signal to show up from the tascam. i tried plugging my guitar into it and it still wouldn't show a signal.
i played a quicktime file on my computer and the speakers plugged into the mobilepre worked, so they are definitely interacting.
so then i decided to unplug the mobile pre and just use a L/R->1/8" jack and changed my input settings to "line in" but still nothing. i then tried again with my guitar plugged straight into my computer, but when i listened with headphones on, it seemed like the internal microphone was the only thing picking anything up -- even though my input settings were set to "line in" and not the built in microphone.
i would prefer to know how to work this with the mobile pre, but i have enough adapters and everything to plug everything straight into my computer. if anyone can help, that would be much appreciated. i've been messing with this for a couple hours and i'm about at wit's end.

i've changed my audio setting both from going into Applications->Utilities->audio midi and turning it onto USB mobilepre
and also by clicking on the apple and going into system preferences->sound
i checked the correct boxes both when i was using the mobilepre and trying to go line in.
is there a GB thing that i also need to check out?

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