Handling anything gets extremely slow after some time

I'm having a strange issue with CS5. Without any apparent reason, the file I am editting becomes very slow with simple actions. For example, moving a (random) object around. Using the arrow keys, it takes every move about a second to complete... there is a lot of weirdness surrounding this, so i'll try to give as much input as I can.
- before this issue comes up, everything is working fine
- there is only line art in the file, simple line art for that matter (squares, straight lines, text).
- if this happens, and i copy paste everyting in a new file, it is working fine again for a random amount of time, until it gets stuck in slow mode again
- Outline mode, has no effect on the delay
- Turned off all effects (only drop shadows) and had no effect
- The file size is around 2,5MB
- Tried tweaking all the settings i could think off (resolution, anti-aliasing, etc), which had no effect.
- Turning off thumbnails in layers has no effect
- sometimes, re-opening the file helps, sometimes it doesn't...
- If the problem is "on", whenever i nudge an object, my cpu shoots to 100%.
- I'm running on a 2010 Macbook Pro (4gb ram), so that shouldn't be a problem (I think), it works fine sometimes as well.
- Tried running OSX in 64 bit, didn't make a difference.
- Tried adjusting the "Document Raster Effects Settings". 9 out of 10 times adjusting that makes Illustrator crash (hard), but after getting it adjusted it had no effect.
- Everything has "align to pixel" on, but turning it off has no effect on the delay.
I this just one of the famous Adobe software annoyances I will have to live with? Or does anybody know a cause of this that I might be able to fix?
Cheers and thanks in advance.
Ben

Tnx for the input Mike, the graphic styles, brushes and symbols palettes are filled with the default fresh-install items. So very few in all of them (only swatches has more than 10 items at first glance). All other programs run fine, it's just Illustrator. The cpu spike to 100% of Illustrator (it's process) only happens on a "nudge" action. After that, it goes back to normal. I have no other heavy programs running. I ran the disk utility and repaired some permission errors (according to the log), there were no other errors there.
I am currently working in "normal" mode (the issue is currently gone because i re-opened it a couple of times), but if I happen to go into "slow" mode again, I'll recheck your list just in case.

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