Help! Adobe Reader XI "Not Responding" in Win7

Does anyone know how to fix my problem.  I am currently running Adobe Reader XI with Win 7.  It was working fine but something happened.  I don't think I installed any new updates but something must have happened automatically.
I have uninstalle and reinstalled - no fix
I have tested with various browsers - no fix
I have updated adobe plug-in
I have updated adobe flash
I have updated adobe air
I am at a loss of what to do - I get work email with pdf's and I can open but as soon as that happens Reader gives me a message "not responding."
Anyone have any ideas?

Thank you, I was able to open Reader by itself and disabled Protected Mode, now
it works.  I don't understand why but I am happy to be able to print docs from
email again.
Thanks! : )

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