I am having a problem with my cs6 running very slow and when i save i am getting an error message that says, "This document is bigger than 2 gb (the file may not be read correctly by some TIFF viewers.) please help

I am having a problem with my cs6 running very slow and when i save i am getting an error message that says, "This document is bigger than 2 gb (the file may not be read correctly by some TIFF viewers.) please help

wen6275,
It looks like you're actually using a camera or phone to take a photo of your monitor.
That's not what is commonly known as a "screen shot". 
It looks like you're on a Mac.  Hitting Command+Shift+3 places a capture of the contents of your entire monitor on your Desktop; hitting Command+Shift+4 will give you a cross-hairs cursor for you to select just the portion you want to capture.
I'm mentioning this because I fear I'm not construing your original post correctly when you type "I am working with a large files [sic], currently it has 149 layers, all of which are high resolution photographs", so I'm wondering if there's some similar use of your own idiosyncratic nomenclature in your description of your troublesome file.
Perhaps I'm just having a major senior moment myself, but I'm utterly unable to imagine such a file.  Would you mind elaborating?

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