I can't open any of my programs

When I turn my laptop on, it takes a long time to boot and when it does, even though I can move my cursor around, I can't open any of the programs. I couldn't even turn it off properly. I had to just shut it down by holding the power button. Any suggestions? I'm really frustrated.
BTW, it started happening when I was using my Verizon Wireless USB device. The program went haywire and wouldn't shut down.

Welcome to Apple Discussions!
Will the machine boot after removing Verizon's USB device?
Will the machine boot after not just removing the device, but also zapping the PRAM as described below:
http://support.apple.com/kb/HT1379?viewlocale=en_US
How old is the MacBook?

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