I can't open files in Photoshop

All of sudden I am unable to open files in Photoshop, either by launching from a folder or opening in Photoshop... all I get is the spinning wheel of death. I've trashed my Photoshop preferences, ran cocktail, repaired permissions and restarted several times but nothing works. I've tried openeing several different files with the same (non) results.
I'm using CS2.
Please help!!!!!

Thanks to everyone who replied to my query.
I repeated the diagnostic steps again (trashed preferences, ran cocktail, repaired permissions) and it worked this time. The only thing different is that I disconnected my peripherals... not sure if that had anything to do with it.

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