I have desktop running Vista and Windows Mail and iPhone 4S.  I receive email fine on the iPhone but when I read or reply or delete email on iPhone it does not "register" on the desktop that I have done so.

It seems like once the messages are received on each device they no longer talk to each other.  They do not "synch" after intital receipt of message.
Please help.

If this is a POP email account that is normal as they don't sync but merely allow devices to retrieve messages from the server.  You have to use an IMAP or exchange account to have changes on one device reflected on the other.

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