I have the following problem: Lightroom encountered an error when reading from its preview cache and needs to quit. Lightroom will attempts to fix the problem the next time it launches.

I launch and relaunch and the same message appears over and over.
Should I uninstall and then re-install Lightroom? Would this fix the problem?

Thanks Jim.
I will give it a try.
My "Lightroom 5 Catalog Previews.lrdata" folder is 12.3 GB in size, so the rebuild will take lots of time...right?
I'll let you know how it goes.
Ciao.
Michel

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