I'm booting from a new LaCie Thunderbolt SSD and it won't wake from sleep.

As my boot drive I have a new 1TB LaCie Thunderbolt SSD Disk. It's connected to a 27" 2.7 GHz Intel i5 iMac (mid 2011). I'm running OS X 10.8.2. Nothing else is connected on Thunderbolt.
Everything runs fine and very fast, with the one exception of not waking from sleep.
When I try to wake it up, the screen illuminates and the desktop is not completely frozen: I can drag windows around, but I can't open applications or do anything with the Finder. I get a spinning beachball if I move the cursor over the menu bar at the top. The only option is to restart.
I've contacted LaCie and they say their devices are "storage devices" and not "system drives". Yet I've been running my system from a 1TB LaCie D2 for at least a couple of years. I pointed out to LaCie support that nowhere on the box does it say their devices are for storage only.
Any suggestions?

@Kappy - not the most useful of replies mate to be honest.After all, there is a strong possibility that this has everything to do with the way OS X and the thunderbolt interface handle wake from sleep states.
@kbrine:
I am having exactly the same problem but with slightly different hardware:
iMac 27 (mid-2011) with Mountain Lion 10.8.2
Booting from a Crucial M4 SSD in an OWC SATA enclosure connected to a Lacie eSata thunderbolt hub (which is connected to the iMac).
In normal use the drive is super fast and works really well.
But my problem is exactly as you describe, put the machine into sleep, and on wake everything appears to come back ok however you can't open apps from the dock and the spinning beachball appears. You can't do anything else and you have to reboot.
Now the interesting thing is that if I put the machine to sleep and then wake it up again within 1 minute everything works perfectly. After a longer period of time - and I'm presuming when the energy saving profile moves to a deeper sleep state (I don't know for sure so speculation from me here) - I get the problem we are having and I have to reboot.
Here's what I've tried so far:
Updated my SSD to the latest firmware.
No firmware updates available for the OWC enclosure nor the Lacie eSata hub (at least, not that I could find)
Turned off bluetooth (others on this forum had a problem with BT interfering with Thunderbolt displays coming back on after sleep)
Turned off 'Automatic Brightness Adjust' (again, based on Thunderbolt Display problems that others have reported)
I've tried out AutoEJECT and Jettison apps that unmount all external drives and re-mount them when waking from sleep. They've made absolutely no difference. Save yourself a few $$ and don't bother buying them from the App Store.
I've tried unplugging and re-inserting the Thunderbolt cable connecting my eSata hub to the iMac. No effect.
And that's as far as I've got. There are only two things left for me to try:: disable 'Power Nap' which - apparently - can also cause problems with Thunderbolt devices during sleep. But I'm not confident with that being the solution. Turn the power off to the Crucial M4 when the problem occurs and then re-power it in the hope that it causes some sort of refresh of the connection to happen. Again, not sure that's a good solution either as I don't want to be powering down my SSD every time I bring the iMac out of sleep!!!
So I too am open to ideas and opinions on what might be causing these wake-from-sleep problems arising when Mac OS is booted from an external thunderbolt drive.

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Message was edited by: appleboyperry

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http://www.lacie.com/support/drivers/driver.htm?id=10053
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9/1/10 2:40:11 PM [0x0-0x1a01a].com.adobe.flash-10.0[269] got type name: Object
9/1/10 2:40:11 PM [0x0-0x1a01a].com.adobe.flash-10.0[269] got type name: Object
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9/1/10 2:40:12 PM [0x0-0x1a01a].com.adobe.flash-10.0[269] CFlashPlayerMDIFrame::LoadFrame
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<SNIP>
9/1/10 3:14:24 PM kernel unknown SIGSEGV code 0
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<SNIP>
9/1/10 3:14:34 PM Safari[165] * _NSAutoreleaseNoPool(): Object 0x1919b1f0 of class NSCFString autoreleased with no pool in place - just leaking
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You may try the following steps:
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Message was edited by: multiphrenic

I've experienced the problem as well. I have the new aluminum macbook with all factory specs and no mods, except that I changed it from smart sleep to the original old mac behavior of instant sleep. It is intermittant and with mine, I've noticed that when the screen is open, the computer appears to be completely off, but when I close the computer the light on the front of the computer comes on. The only resolution I've found so far is to hold the power button for 5 seconds for a hard power down and then push it again--everything works fine.
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I'm booting from a new LaCie Thunderbolt SSD and it won't wake from sleep.

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