"Int'l No" symbol on startup

On my early-2009 8-core 2.28g MacPro (10.6.?.) I now get the international no symbol (circle with a diagonal line through it) when attempting to start up. First, I get the gray startup screen with the Apple logo, then the apple turns into the no symbol.
This started after I experienced Word and Excel not responding. Went to Force Quit and quit both apps. Then I noticed it said Finder was not responding either. So, maybe the wrong thing to do, but I relaunched Finder. Finder never came back, only a plain blue screen (my regular screen color). Nothing was working so I powered it down.
Anybody have any thoughts what happened? I'd boot off the system install disc if I could remember how to get the optical drive open in this circumstance, if possible.
Thanks for any ideas.

+I'd boot off the system install disc if I could remember how to get the optical drive open in this circumstance, if possible.+
Hold down the (left) mouse button at startup. Don't make any changes to the problem disk unless you have a current backup. If you don't have current backup, you need to make one, if possible, before you do anything else. Either boot from another hard drive with a clean installation, or start the Mac Pro in Firewire target mode and attach it to another Mac.

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