Iphone 3g not able to Sync with Itunes

Hello,
I have iphone 3g with OS 2.2.1 and itunes 8.1
I m not able to sync with i tunes.
Whenever i connect phone, Itunes get hung .
Sometimes it displays foll message:
Itunes was unbale to connect iphone because it recieved an invalid response.
If i restart and connect it gives
Unable to Load Dataclas information for the iphone.Try reconnecting.
I did every thing
De-install,Re-install each and every thing based on suggestions at various places,still no use.
Even tried Syncing with Other OS XP , same problem-> Itunes gets hanged.
Im absolutely clueless about whats happened.
Somehow i was able to update the OS to 2.2.1 .
Dont know where the problem is....
Can any problem with Hardware lead to Such error..If yes..What are the probable hardware reasone...
Software wise i dont think anything is left unchecked,still any suggestions, help welcome..
Im really in need to sort this out as cant sync anything..the phone is blank wiht complete HDD free....No use.....
Please Please Please Help..!!!!!!!!!

As I read you updated your iPhone to 2.2.1. That means that maybe this cause the problem.
Sometimes when I connect my iPhone to iTunes I saw the message what says that "iTunes was unable to connect to the iPhone... " but if I reconnect my iPhone then iTunes recognize my phone and everything is OK.
If the reconnecting does not help you then I advise that reset your iPhone with 'Erase All Data and Settings'. Settings > General > Reset > Erase All Data and Settings.
If you reset your iPhone with 'Erase All Data and Settings' then your iPhone will delete your files and also the 2.2.1 software update and after that it will run with the original software what you bought with it.
The reset takes approximately 2 hours. And this is delete everything from your iPhone.
So, as it seems you can't back up your iPhone, that means everything what is on your iPhone will be deleted except if you don't have them on your computer.
After you reseted your iPhone, try to connect with iTunes. If it won't works then try it on an another Mac or PC and if you can't sync your iPhone at all, you have to take your iPhone to your carrier for a service.
Important note: After you reseted your iPhone, it will please that connect to iTunes to activate the phone. If you can't connect to iTunes your phone, you won't be able to use it!
As you know, without activating you can't use the iPhone.
If you can do the activation then you probably will be able to sync it.
If you can't be without mobile phone and just the iPhone what you've then don't do that until you maybe could miss your phone (I mean if you iPhone have to be serviced).

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