Iphone 3G will no longer sync with MacPro

my iphone 3G will now not sync. I get this: The iPhone "TM's iphone" cannot be synced. The disk could not be read from or written to.
Has anyone seen this? Is the "disk" the computer (MacPro 10.6.8 running latest itunes) or the iphone 3G 4.2.1 o.s.?
Thanks.

Hey Allan,
The funny thing is that I don't get that option on my mac in prefs.
I get it on my windows itunes (which is where I set-up my account and sync most things)
I use my mac purely to sync with ical for a back-up for my calander and address book.
Had no problem before a day or so ago?
thanks!

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