IPod 80 GB sync failures. Errorr -46

I keep getting iPod cannot sync error -46 messages when I try to load up new tunes. What does this mean? Why does it happen repeatedly? I'm getting bored of constantly resetting my iPod, is it back to the store time or is there something I can do?
Cheers.
Fred

I have the same problem, on the same iPod model, and it is not the USB cord or port, because my older iPod Mini still syncs just fine. I have tried most of the steps offered in that article - including the 5 R's, deleting registry limits and changing the power management settings for the USB Root info in my Device Manager.
Nothing has helped. Has anyone had luck solving this issue?!

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