Is it OK to use USB 2.0 connection for Glyph external drive and Mac Pro as project drive?

Is it OK to use a USB 2.0 connection for Glyph external drive and Mac Pro as project drive? I was told by Sweetwater tech support to use Firewire, but both the FW400 and FW800 connections crash my audio interface software mixer (Presonus' "Universal Control" software).
Both Firewire connections also create a 10 second hang for each Command-Save that I do.
USB 2.0 for the external drive seems to be working so far, but is there some reason I should be wary of using this as my go-to project drive? In other words, I am imagining that there was probably some definite reason that the tech support guy mentioned not to use it. But maybe not. It's a brand new Glyph. In any event, it's nice to have the 10 second hang eliminated, and I was just looking for some advice, since digging into the Presonus software issue could take some time.

If you have a mac pro, why not stick the external HDD inside via one of your many SATA cables & have it run 9 times faster than your USB?
Or stick a HDD CADDY in your mac pro, so you can slot in a full sized 3TB HDD for recording, and when you are done, pull it out & slip it in an external enclosure if you need to take it places?

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