Is there a cure for persistent file corruptions across the suite?

i am having terrible and consistent problems with file corruptions across the suite. for example…
1: i collected for output (indesign) – corrupted over 100 small images that were linked.
2: opened an indesign job and all linked files failed to update and could not be imported (simply would not import those files and were all corrupted).
3: had a hang in photoshop followed by a 150:30 error (would not open any of my applications). this prompted a clean install of system and adobe cs4 see below
4: most recently, had a hang in photoshop (photoshop will also no "force quit") whilst indesign was open. two of my image files corrupted and, most surprisingly, all my illustrator files that i had placed also corrupted (will not even open in illustrator any more). illustrator was not even running at the time, so, get this – a hang in photoshop destroys illustrator files simply because they are placed in indesign.
this last event has made me more certain than ever that there is a fundamental problem at the cs4 core.
can anyone help?
please note the following:
i am running a macintosh imac, 2.66 GHz Intel Core 2 Duo (latest imac), with 4 GB 1067 MHz DDR3 ram.
before this last disaster, i had reloaded the system software (archive and install), and updated it all the way to version 10.5.8
i then uninstalled the creative suite, ran the cleanscript from adobe, reloaded the creative suite, downloaded all the cs4 updates
(so, latest mac, latest system, latest cs4 – all clean installs).
is there something i can do? or is this just a very unstable and disappointing upgrade – i have had nothing but problems from day one!
many thanks if anyone has any advice.

Re: 150:30 error:
Please try this KB article's solutions, and report back on how it went for you. If you can provide details about any recent OS updates, backups, or migrations, that would help is nail down the root cause of the new rash of this error for Mac users recently:
http://kb2.adobe.com/cps/512/cpsid_51260.html

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