ITunes will not open, Error message -45054

My itunes on my Mac will not open, all that comes up is this message
"An unkown error occurred (-45054)"
I can't seem to find the source of the problem and all the drop downs from the menu bar are not able to be clicked on so can't really get anymore informaion out of it.
can anyone help me out?

Murray3703, only one other time did this happen to me.  It was over 6 years back when I had an iPod Nano and after doing the reinstallation, it wiped out all of the content and applications and corrupted by Nano to the point Apple said it could not be fixed.  I had no other things corrupted on my laptop.  So, I know it was not a virus.
I have tried fixing the problem with redownloading and "repairing" the problem but, it did not work.  Since the Nano incident, I am somewhat reluctant to do this for fear that I will loose all of my content and paid applications to apple?  I also have Windows 7. 
Did you have any issues with uninstalling and reinstalling? Thanks.

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