Itunes won't open, won't force quit, won't anything

This problem started about a month ago and now it's critical.
When I click the itunes icon, it bounces and then freezes. itunes won't open. It also won't force quit. I can't shut down because, it says, itunes won't quit. I have to hold down the power button 7 seconds to shut down and then restart. My IT guy at work (who is a Mac person) showed me how to repair permissions and the first half dozen or so times this happened, that worked. Now it won't. I've tried uninstalling and reinstalling itunes. I've tried reinstalling and repairing permissions. I've rebooted and repaired and reinstalled.
This is the kind of thing I switched from PCs to get away with.
Does anyone have any ideas? I really need to be able to use itunes.
Thanks,
Teresa

Teresa
Here are some basic to try in turn, see if any one will help:
Ensure that you have the latest version of the OS and Quicktime and iTunes.
1. Delete the com.apple.iTunes.plist file from the home / library / preferences folder. You'll need to reset your User options afterwards.
2. Create a new account (systempreferences -> accounts) and see if the problem is repeated there. If it is, then a re-install of the app might be indicated. If it's not, then it's likely the app is okay and the problem is something in the main account.
Regards
TD

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