LR4 Problem: The file could not be edited because Adobe Photoshop CS6 could not be launched.

Is there a fix for this?  When I try to edit an image in Photoshop from Lightroom 4 (CTRL+E), Photoshop CS6 launches immediately but with no image.  In Lightroom 4, after about two minutes, the message box appears saying "The file could not be edited because Adobe Photoshop CS6 could not be launched."  When I click OK, the image promptly opens in Photoshop CS6 like normal.  This wan an itermittent issue for me after the LR4.1 release.  I was hoping that LR4.2 would help, but now I get the error every time.
System
Lightroom 4.2 x64
Photoshop CS6 v13.0.1 x64
Bridge 5.0.1.23 x64
Windows 7 Pro x64
AMD Six Core / 3.9 Ghz
16 GB Memory
NVidia Quadro 1 Gb Video
Scratch space on three drives

This may be a cooincidence, I starting having problems after I started using a Nikon D800, which has 36MP files.  LR4 released at the same time as the D800.  LR4 shows signs of struggling with the larger files, which are typically 280MB TIFFs for the D800, like freezing for several seconds when using an adjustment brush or going into a spasm with the crop tool.  Because Photoshop does not have similar large file issues, I'm doing more basic work in Photoshop, like cropping, dodge and burn, exposure adjustment, etc.
Because Photoshop otherwise runs fine, and appears to read all the prefernes properly mid-issue, to get a better idea of what's going on, I turned on Process Monitor from Technet. For what it's worth, LR4 appears to touch the Photoshop preferences before it launches Photoshop.  LR4 must have a memory leak in that corrupts the Photoshop preferences file in a way that makes no difference to Photoshop.
My weekend project is to try Capture One to see if I can spend more time on photography and less troubleshooting Adobe problems.  As it stands, LR4 is not usable for me.

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