Mac Mail suddenly gave me a fatal error message

Hello there:
Yesterday out of the blue, I got an error message (wish I would have written it down) that Mail had a fatal error and needed to be re-set. And a button to click to start now. Which I did. It took about 30 minutes to remake, and now I show that I have 6600 unread messages and I don't. The 2nd problem is now I can't sent attachments as all. I get an error message theta they are too big - when they're not.
Hoping someone can help,
Susan
System:
Mac OS X Version 10.6.4
2 GHz Intel Core Duo
Memory 1 GB 667 MHz DDR2 SDRAM

Are you following these instructions?
Disconnect the USB cable from the device, but leave the other end of the cable connected to your computer's USB port.
Turn off the device: Press and hold the Sleep/Wake button for a few seconds until the red slider appears, then slide the slider. Wait for the device to shut down.
While pressing and holding the Home button, reconnect the USB cable to the device. The device should turn on.
Continue holding the Home button until you see the Connect to iTunes screen.
iTunes will alert you that it has detected a device in recovery mode. Click OK, and then restore the device.

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