MacBook can no longer see internal hard drive or replacement

This morning, when forcing a restart of a MacBook (It was non responsive in sleep) it restarted with 2 or 3 of those ominous tones and then the standard Mac startup sound. I then got the blinking folder indicating there was no system disk available. Disk utilities from a OS disk did not see the drive and when in target disk mode, the other computer did not see the drive. System Profiler did see the SATA hardware but no device was attached to it. Went out and bought a new SATA drive and installed it. Exactly the same problem. Tried resetting the PRAM and nothing. Suggestions?

Paul Kleeberg wrote:
This morning, when forcing a restart of a MacBook (It was non responsive in sleep) it restarted with 2 or 3 of those ominous tones and then the standard Mac startup sound. I then got the blinking folder indicating there was no system disk available. Disk utilities from a OS disk did not see the drive and when in target disk mode, the other computer did not see the drive. System Profiler did see the SATA hardware but no device was attached to it. Went out and bought a new SATA drive and installed it. Exactly the same problem. Tried resetting the PRAM and nothing. Suggestions?
Have you tried contacting AppleCare?

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