MAIL cannot update your mailboxes---error in MAIL 2.1

"MAIL cannot update your mailboxes---"
Have 26 Gb of space left and found the fix to delete the Envelope Index file. I moved Envelope Index to the DT and relaunched MAIL. It seemed to import 1200 items, then it just goes to colored wheel of death. Had to Force Quit 3x.
Any ideas? Im trying to help a senior fix this problem. She cant get her email.

Hi Steve,
Not certain, but this can fix myriad Mail problems...
Safe Boot from the HD, (holding Shift key down at bootup), it will try to repair your Disk Directory while the spinning radian is happening, so let it go, run Disk Utility in Applications>Utilities, then highlight your drive, click on Repair Permissions, then move these folder & file to the Desktop.
Move this Folder to the Desktop...
/Users/YourUserName/Library/Caches/Mail/
Move this file to the Desktop...
/Users/YourUserName/Library/Mail/Envelope Index
Reboot.

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