Mail does not send unless I close out and reopen it.

Usually if I do not close out of an email session, when I go to check my messages later my mailboxes show a "!" symbol, indicating there is an issue; additionally, messages that I am trying to send do not go.  Once I close out and sign back in I am able to receive and send messages with no problem.
This is only on an issue when I am using the mail function on my iMac - not when I am checking from other computers; and
This is not a password problem.  The only thing I need to do to receive messages is close and reopen the application - once I do that, messages are received (and sent) without problems.
I don't recall if I have this issue when checking mail from me.com on my home computer or others, as I rarely check messages from there.
I have an iMac 7.1 with OS 10.6.8 (not 10.4.11 as mistakenly checked off below).  This has been happening for several weeks, if not months, but since closing out and getting back into Mail was not a problem I haven't reported the issue until now.  Thank you very much for any assistance you can provide.

As a follow up, I've discovered that this is happening in IE on the same websites. When I log into a different computer and test the same scenarios, the cookies do not disappear. It seems to be a problem on my computer. However, if anyone knows how to fix this, I'd be glad to hear it.

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