Mail Stops Responding Immediately after Starting up

Mail is not behaving today. As soon as I start it up, the beachball spins for about 15 seconds and the app stops responding. Any assistance would be grand.
Works fine on my Macbook and I have already checked nd repaired permissions.
Thanks!

Verify/repair your disk (not just permissions), as described here:
The Repair functions of Disk Utility: what's it all about?
Now, go to Apple Menu > System Preferences > Network > Show: Network Port Configurations, and make sure that the configuration used to connect to Internet is at the top of the list.
Finally, try launching Mail under the following conditions (you may need to force quit it first if it's running):
1. Holding the Shift key down until the main window appears.
2. With no Internet connection.
Post back with your observations.

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