Mouse settings are not being saved

I just did a clean install of Lion (10.7.5) on a new SSD in a mac pro 1,1 and am having problems with my mouse settings. The settings are not being saved. When I change any of the buttons, nothing changes.
It's not a hardware problem with the mouse. If I boot up to my previous os drive, lion 10.7.5, the mouse settings are correct and function properly.

FOrgot to add, this is the basic wired mouse. I've also tried the wireless bluetooth mighty mouse as well with the exact same results.
I've tried removing the plist files with no success

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Welcome to the Apple Discussions!
Is this just for new settings that won't stick? Or have all your original settings reverted to the defaults? Have you started up from your Mac OS X install disk and used the Disk Utility to "repair disk"? Do you have a backup of your important files?
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reset your preferences -
after effects: http://helpx.adobe.com/after-effects/using/preferences.html
dreamweaver: https://helpx.adobe.com/dreamweaver/kb/restore-preferences-dreamweaver-cs6-cc.html
flash: http://helpx.adobe.com/flash/kb/re-create-preferences-flash-professional.html
illustrator: http://helpx.adobe.com/illustrator/using/setting-preferences.html
indesign: https://forums.adobe.com/thread/526990
photoshop: https://forums.adobe.com/thread/375776
photoshop elements: http://www.photokaboom.com/photography/learn/Photoshop_Elements/troubleshooting/1_delete_p references_file.htm
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I logged out, trashed all Apple cookies and logged back in again. My settings for viewing topics had been saved as I wanted.
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Later I logged back in and my OLD settings had come back again.
<--- not pleased.

589/3035
Hi Tom,
"Maybe I shouldn't be doing this in Firefox?"
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