My MacBookPro has a white screen with a grey file folder in the center of the screen with a white question mark blinking in it. What does this mean?  And how can I get my computer back up and running normal?

My MacBookPro has a white screen with a grey file folder in the center of the screen with a white question mark blinking in it. What does this mean?  And how can I get my computer back up and running normal?

Start up in Safe Mode.
http://support.apple.com/kb/PH14204?viewlocale=en_US
Repair Disk.
http://support.apple.com/kb/PH5836
Reset PRAM.
   http://support.apple.com/kb/PH14222

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