Photoshop CS5 does not respond to Lightroom

Hi. I have just recently upgraded both Photoshop CS4 to CS5 and Lightroom 2.7 to 3.0. They're great upgrades and am enjoying the new features. However, there is one hangup that I am running into. When in Lightroom, I do a right click over an image to Edit the Image in Photoshop CS5. Most of the time the image will then open in Photoshop and I can then proceed to do my edits. But, after a short while (after a couple hours), this procedure stops working. When I click in Lightroom to Edit in Photoshop CS5, Photoshop will begin to load up, but then the image to edit never appears. I then quit Photoshop and reload it, but then it still doesn't respond to Lightroom. After quitting both programs and retrying the whole process, Photoshop still won't respond.
The only way to fix this I've found is to restart or log off the comp (I'm on a mac with OSX 10.6). Some on here have said to delete the preference files. I've done this, but still no luck. I've deleted Photoshop CS5 and reinstalled it, and still the problems persists. I've updated my CS5 to version 12.0.1, and still the same problem. Has anyone else out there experienced this problem?
Thanks

Worst case: trashing prefs by keeping ctrl-alt-shift pressed while starting Photoshop (and then using the dialog) should allow you to open it.

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