Photoshop cs5 not working correctly anymore

'm running windows 7, and am using PS CS5. It has started developing a few problems that are becoming very troublesome. My system is 64-bit running intelcore i5 2320 3.00 gz with 6gb ram. It's a Dell which is probably the main problem to begin with, but here goes.
The first problem:
It won't open any secondary files on the first try. When it doesn't, I have to scroll through folders, then try to re-open the file. Major headache. On my preferences under performance, "Open GLdraw" is not checked.
The second problem:
It often won't let me make any image adjustments on a file, or on a layer unless I close the program and restart.
New problem: saving files in an unrecognized format. I usually can recover some if I open them with paint, but I find this ridiculous.
Anybody have any of these problems, or know of a fix other than re-installing photoshop?
Thanks!

No, didn't work. It's back to it's same old tricks. Won't open a file from another folder on the first try, or make image adjustments without restarting PS. I suspect Extraterrestrial intervention.

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Wow, I'm so glad I found this thread. This problem has been dogging me for years, and it's so sporadic that I've been afraid of breathing the wrong way lest I somehow incur that diabolical Program Error dialog. I'd managed to reach a truce with Photoshop CS5, getting it into a barely working state, and avoiding all updates... until Lion came along today. Then I updated to CS5 12.0.4, and the Program Errors were back again.
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Message was edited by: charles badland

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Bump.
Boilerplate-text:
Are Photoshop and OS fully updated and have you performed the usual trouble-shooting routines (trashing prefs by keeping command-alt-shift/ctrl-alt-shift pressed while starting Photoshop after making sure all customized presets like Actions, Patterns, Brushes etc. have been saved and making a note of the Preferences you’ve changed, 3rd party plug-ins deactivation, system maintenance, cleaning caches, font validation, etc.)?

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[email protected]

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