Photoshop CS5 unable to open for edits from Lightroom 3

Have been experiencing numerous issue with the new LR and Photoshop not playing nice with each other on my Mac Pro w/10.6. Photoshop CS5 is will open in 1 attempt out of 8, and won't open from LR for editing purposes (it did once). Have been using in 32 bit mode to accommodate NIK and Topaz filters. I have reinstalled three times so far. Anyone got any ideas?

Try deleting the prefs folder for Photoshop. Mine was doing something like this where it would not open the image inside
of CS5 when you right click on the image and try an "open with". But it would work from the menu, most of the time. The cost is having to recreate custom settings inside Photoshop but since my CS5 was a new install as was LR3, it did not matter to me. It did require a reboot for the new preference file to fully take effect.
From Adobe's own workaround
5. Re-create the Photoshop preferences files.
Re-create the Photoshop preferences file to eliminate problems that a damaged preferences file might cause.
Note: Re-creating the Photoshop preferences file restores settings to their defaults.
To re-create the Photoshop preferences file:
Quit Photoshop.
Rename the Users\[username]\Library\Preferences\Adobe Photoshop CS3 Settings\Adobe Photoshop CS3 Prefs.psp folder to Adobe Photoshop CS3 Prefs.old.
Start Photoshop. Photoshop creates a new Adobe Photoshop CS3 Prefs.psp file.
If the problem continues, then the Photoshop preferences file isn't the cause. To restore custom settings, quit Photoshop, then delete the new Adobe Photoshop CS3 Prefs.psp file and restore the original name of the previous Adobe Photoshop CS3 Prefs.psp
Here is another adboe document for file locations that are important
http://kb2.adobe.com/cps/333/333660.html

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