Premiere Pro CS6 Audio Issues

Question

We have been testing Premiere CS6 on our first job for the last week. However, we are running into some major audio issues:
1. When clip is loaded into the source viewer, and you jump to through the cilp, the audio lags behind until you stop and wait a few seconds for the audio to catch up. This is a major hinderance when trying to edit quickly with clients in session. This also happens on the timeline when jumping around. These problems never occured in Avid or FCP running the same media.
2. With no rhyme or reason, the audio (from source and timeline) sometimes just doesnt play. The meteres will be moving and the video will play, but the audio wont be coming out. Sometimes you hear a noise as if someone was playing with the audio cables. Also, sometimes the meters dont even move, to suggest there is no audio again video is playing, when infact there is.
These problems have occured accros multiple machines, with media running from both our server, and local hard drives. Our facility runs a NAS that pushes 110/MB/s over ethernet from a 16TB RAID6 (that is SAS connected to the server). One machine is running OSX 10.8, with Black Magic Intensity Pro, 20GB Ram, NVidia Quadro 4000. Another is running OSX 10.8, with AJA IO Express, 16GB Ram, NVidia 4000. and the last is running 10.6.8 with Black Magic Intesnsity Pro, 12GB ram, and NVidia GTX something or other (unsupported card).
Has anyone else gotten these issues? Like i said, i have tested the media from the server and from the local hard drives. We are pushing Apple Pro Res HQ, have also tested Pro Res LT, Pro Res 444 and Canon H.264.

Answer 1

For me it wasn't a RAM issue, I had more than enough to process the audio I had in my project.  This quote from a Creative Cow post worked for me.
"Try deleting your .cfa files for the media in question, and then don't mess with the project until they are done re-conforming."
Here's the original post:
http://forums.creativecow.net/thread/3/926011
I don't know how to figure out which .cfa files are associated to specific media files, so I just went to where they were cached and deleted all of them.  Open your project again and you'll see a little yellow bar in the lower left-hand corner of the Timeline window showing  that it's re-conforming your media.  Don't even think of touching the computer while it's doing this... I was so paranoid that I didn't do anything else (check e-mail, open a web browser, work on a Word doc, etc.) until Premiere was totally finished.  After that my audio played fine for the rest of the project.
One thing that's tricky and took me a while to figure out is that if you're using multiple drives, you have to be careful to make sure you're getting ALL of the .cfa files.  If you've set the project to cache your files on a external drive, and then open a  project on a different drive without having that external connected, Premiere will set the cache folder to its default location (usually on your host computer's main hard drive).  I didn't realize this, and had the audio drop-out issue, so I deleted the .cfa files but the drop-out didn't go away.  I found out that Premiere had reset my media cache folder, and had cached the corrupted .cfa files on my main hard drive.  Once I deleted them there and let the computer re-conform, the  audio played well again.
Hope this helps, let me know if you have any questions.