Problem with Audio Distortion

I have a large iTunes (v7.2) library with over 110,000 tracks, which I run through the digital line out of a Mac Pro running OS X 10.4.10. For some reason, I'm suddenly getting serious audio distortion on many of the tracks. Some tracks play with distorted, crackling, others play extremly softly. Others play fine. What makes the problem strange is that it occurs with different tracks encoded in different ways: MP3, unprotected AAC, protected AAC, and Apple lossless tracks are all affected. There doesn't seem to be any rhyme or reason to which tracks are affected. Furthermore, I've verified that it's not the tracks themselves...if I run the same tracks through iTunes on another computer (via library sharing), they play fine. Finally, I've turned off Sond Check, Sound Enhancer, and the Equalizer, but the problem persists.
It's very frustrating! If anyone can please help me, I will be extremely grateful. Thanks so much!
Mac Pro   Mac OS X (10.4.10)   iTunes 7.2
PowerBook G5   Mac OS X (10.4.2)  
PowerBook G5   Mac OS X (10.4.2)  
PowerBook G5   Mac OS X (10.4.2)  
PowerBook G5   Mac OS X (10.4.2)  
PowerBook G5   Mac OS X (10.4.2)  

It is set to 256 by default and even with an higher buffer size it doesn't change at all

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