Purchase organization filled PR not allow to change desired vendor in PO

Hello All,
i am facing a issue.
if you set a "Desired Vendor" in the PR, this can be copied as default value in the PO Vendor field when dragging & dropping the PR item in the Shopping Cart icon of transasction ME21N.
if purchase organization is empty in PR with desired vendor,   we can modify the vendor in the PO.
if Purchase organization filled in PR with desired vendor, we could n't able to modify the vendor in PO... its appearing grey unable to edit the vendor.
here my question is   whats is the relation purchase organization not allowing to change the desired vendor in po.
what are the configuration related to this issue.
Actually   we want to modify desired vendor in PO irrespective of the the purchase org filled or empty in PR .
Please explain in details with an example
Thanks and regards,
Sathiya

Hi
vedor must assigned to P.Org...
Check once that You are copying existing PR to a PO (having fixed vendor in PR)?
And also check PO doc type settings whether vendor field is mentioned as optional/required.
Regards,

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Purchase organization filled PR not allow to change desired vendor in PO

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