System not allow to change PR  QTY after create PO

Dear Experts,
I have one scenario after create RFQ & PO no body can change the PR qty.
How can i restrict please guide me.
Regards
Aamir

Use BADI :ME_PROCESS_REQ_CUST
Here with the help of the ABAP person write a code like while saving the PR in me52n system will check in the background if there is any entry against filed EBAN-EBELN...if found then system will throw a customized error.
you can also try out by making message 06-152 as error message.
Regards,
Indranil

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