The application system preferences can't be opened

After limiting spotlight searches to external shared hard drives, I cannot eliminate this limit because when I go to System Preferences to change Spotlight, I get an error message "the application System Preferences can't be opened". How can this be reset?

No error code.
I finally went to caches in my library and delted "com.apple.preferencepanes.cache".
I tried to restart my computer but it hung up. I unplugged it and re started.
Maybe primitive. But it seems to be working so far.
thanks!

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