Unable to open/edit project in project professional form PWA(project server 2010)

i have been working perfectly and opening my projects with project professional from PWA
All of a sudden,i get this error: no permission to read enterprise global file when trying to edit my projects in project professional from the PWA
i have also tried opening the project from project professional directly and it says (you do not have sufficient permissions to  perform the requested action)
please what is the cause of this issue and what can i do to resolve it?

Hello kehinde,
The cause of this problem is somebody changed something.
To resolve, I would clear out the cache to see if that resolves anything.
Then, I would reboot system and see if that resolves.
If still no go, then I would look into security settings, and start doing some detective work.  I keep a version of project server in a separate instance, that is completely out of the box, so I can have a reference point for settings.
If still not solution, then I would resave the global file settings.
Cheers!
Michael 
Michael Wharton, MBA, PMP, MCT, MCSD, MCSE+I, MCDBA
www.WhartonComputer.com

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