Unable To Save Quark XPress File In Mac OS 10.2.8

I have been trying to save a layout I created using Quark XPress 6.1 on an iMac with a 10.2.8 OS. When I first created the document, I was able to save it with no problem. However, after I had done some more work on it, I tried to save the changes -- but all I got was a message that said "Cannot find required volume or folder [-35]." The folder I have been trying to save it to is still there. I then tried using Save As to save it in a different location or under a new name -- but then I get an "Unknown error [-51]."
I tried to solve the problem by consulting Help, but all I was able to find is that apparently the error is occurring with the OS, not with Quark XPress.
I spent hours working on this document and will be sick if I am unable to save it. Can anyone possibly help me? I'd really appreciate it. Thanks.

How big is your hard drive, and how full is it?
How big are files like the one you are trying to save?

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