Unable to send mail- mail remains in outbox and I receive error message

Ok, I have used Mail for years. All of a sudden I am unable to send mail. The mail goes to the outbox and then I receive the following error message.
This message could not be delivered and will remain in your Outbox until it can be delivered.
The server "smtp.mac.com" refused to allow a connection on port 25.
I can connect to webmail of course and send mail that way.
I receive mail perfectly.
Not sure what to do...??
Thank you for any help with this.

Read the following article, which applies to all versions of Mac OS X (not just Mac OS X 10.4.2 and earlier as the article states) and can be useful for other mail accounts as well (not just .Mac):
.Mac: Server timeout alert message when sending email

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