What is the best way to clean up your mac and make it faster and run to an optimum level?

Hi Everyone, Hope all is well
Iv been running my mac pro for a long time now, its a Mac pro, 2x 2.26 GHz Quad Core Intel Xeon. 12 GB 1066 MHz DDR3 Ram
Over time now it has become slower, at the moment its still running fine but im sure over time it has probabally collected unwanted data etc. i just dont want it to become a problem as its only going to be used more and more... i now notice that some of the regular programs which i open do take a little while longer to open and i sometimes see that little round Mac loading the sign (the round multicolor wheel).., is there a way to clean the mac up? so that it can run more smoothly and just a better over all feel.,,, the machine is still running beautifully but its time i give it more care and revive it a little more..
What are the best ways to do this, i dont trust any of these non apple based products which claim they can clean ur Mac etc.
Any solutaion and advice that u guys can give would be great and i would be very thankful
Thanks in advance

For immediate speed improvements, upgrade to a Solid State Drive and upgrade your conventional hard drives to new ones, because the newer ones are faster at reading and writing than the ones from 5 years ago.
By Re-installing your OS onto a solid state drive, the system will boot much faster, and your programs will launch much faster.
I use a small SSD (only 60GB) which contains only OS X and all my apps.  All of my personal files are on the large mechanical hard drive.  If you still use the drive that shipped with the Mac, then it might be a good idea to replace it.
Depending on what kind of work you do, then additional RAM will help.  Swapping CPUs should only be done if you are really in need of the improvements they would bring. 
You appear to have the 2009 dual-CPU Mac Pro, which is the most challenging model to swap CPUs into.

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