When using BW Bex query analyzer users cannot change reporting queries ....

Issue: When using BW Bex query analyzer users cannot change reporting queries. Any attempt to change queries results in errors.
Error: BEx Query Designer: Run-time error '-2147221499 (80040005) Fatal Error - Terminating
Impact: Business reporting is currently being negatively impacted because users cannot modify queries, cannot change filters for fiscal period and fiscal year.
OS / MS Office Suite being used: Vista & Office 2007
Backend System: BW 2.0B
Frontend System: Being a large organization, we have a controlled environment wherein all users will have the following applications installed by default:
1. SAP Client Base 7.10
2. SAP BW 3.5 Patch 4
3. SAP BI 7.10 Patch 900
4. SAP GUI 7.10 Patch 12
Does anyone has any idea as to why we are getting this error? Is it a Vista issue? Is it a front-end issue?

Just a thought - did you guys apply any Microsoft security patches before this started happening - we had a similar issue in other SAP application due to MS security update. Raise an OSS with SAP

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